Shooting the tentacle's weak spot at that moment causes it to flail madly and hurl the object in a random direction, generally not towards the tower. Each of the Slug's tentacles pauses briefly before throwing the object it's holding.Fire should be diverted to any explosive gas tanks the Slug hurls at the cannon, since they do more damage to the tower than hull debris.Only then does it rear up its tentacles to tear the ship apart, exposing their weak spots in the form of yellow bulbous masses as it hurls chunks of the ship's hull and explosive gas canisters at the ADS Cannon tower. The Slug is initially placid and won't attack unless fired at.

However, Dead Space: Extraction proves this point incorrect as Nathan McNeill disabled this particular ADS cannon (and possibly the system itself), the cannon would have been unable to fire at anything until Isaac came to manually reactivate it. The Slug was originally thought to have arrived on the ship after the initial infection, due to the fact that ADS Cannon 48 would have engaged it. Immediately following the Slug's demise, it releases its grip on the Ishimura and begins floating off into space, at which point Kendra Daniels is able to broadcast a warning to the USM Valor, telling them not to open the escape pod they retrieved. Defeating the Slug requires the destruction of all five tentacles - while at the same time using the cannons to destroy the incoming debris thrown by the Slug. During the fight, it will use its five tentacles to hurl objects at the tower, with each tentacle having a weak point appearing as a bulbous yellow mass close to the slug's body.

The Slug has to be fought using one of the Ishimura's anti-asteroid cannons, specifically ADS Cannon 48.

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